Studies on Neurospora chromosome segment duplications (Dps) performed since the publication of Perkins's comprehensive review in 1997 form the focus of this article. We present a brief summary of Perkins's seminal work on chromosome rearrangements, specifically, the identification of insertional and quasiterminal translocations that can segregate Dp progeny when crossed with normal sequence strains (i.e., T × N). We describe the genome defense process called meiotic silencing by unpaired DNA that renders Dp‐heterozygous crosses (i.e., Dp × N) barren, which provides (...) a basis for identifying Dps, and discuss whether other processes also might contribute to the barren phenotype of Dp × N and Dp × Dp crosses. We then turn to studies suggesting that large Dps (i.e., >300 kbp) can allow smaller gene‐sized duplications to escape another genome defense process called repeat‐induced point mutation (RIP), possibly by titration of the RIP machinery. Finally, we assess whether in natural populations dominant RIP suppressor Dps provide an “RIP‐free” niche for evolution of new genes following the duplication of existing genes. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Description: Professor M. Hiriyanna (1871-1950) is recognized in learned circles both in India and abroad as an outstanding authority on traditional Indian philosophy. This monograph attempts to bring his contribution to Indian philosophy to the notice of a wider circle of readers. Deeply versed in Sanskrit classics and equally proficient in English literature, Hiriyanna worked with single-minded devotion to the cause of Indian philosophy and literary studies. This volume brings together the cream of Hiriyanna's contribution, spread over his numerous articles (...) and books, in one conspectus and evaluates his place among the builders of Indian philosophy. Though Hiriyanna did not claim anything like a philosophy of his own, he had a distinctive perception of both the general spirit and the specific concepts and doctrines of Indian philosophy. This book seeks to highlight Hiriyanna's characteristic approach to Indian philosophy in all its aspects. It starts from the general standpoint of Hiriyanna in regard to Indian philosophy and takes the reader through the details of his interpretation of Indian metaphysics and value investigation. Brief, significant quotations from Hiriyanna are given at appropriate places to bring the reader's attention directly to Hiriyanna. The numerous references given to Hiriyanna's works will also be helpful in the study of Hiriyanna in the original. (shrink)

The question of form and content is one of the fundamental questions of esthetics and the theory of art. However, it remains unresolved in many respects. Certain of its aspects still have not been investigated, and others have been treated only very sketchily.

Artist Leonid Filatov. Kakimi raznorodnymi talantami on odaren! YArkij kinorezhisser. Blistatel'nyj parodist. Skazochnik. I vse, chto on delal - pechal'noe i mudroe - na radost' nam. Ego poeziya sozdaet obrazy dushevnoj zhizni lyudej, nepohozhih drug na druga, dazhe protivostoyaschih drug drugu. Eto svojstvo istinnogo iskusstva. Komedijnaya p'esa po motivam bessmertnogo romana Dyuma otkryla nam esche odnu storonu ego darovanij.

Exegesis of the philosophy of Madhva, 13th century founder of the Dvaita (dualistic) school of Vedanta.

The study of the republican Roman Senate was revolutionized by Professor Broughton's Magistrates, and to a lesser extent more recently by Professor Lily Ross Taylor's Voting Districts of the Roman Republic. Naturally, neither of these two great works rounded up all the available evidence without exception, and a considerable amount of mopping-up has been carried out. More remains to be done, however, and this article aims at providing some further information on republican senators, their tribes, and their origins, as an (...) addendum to M.R.R. and its Supplement, and the prosopogra- phical chapter of Professor Taylor's book. (shrink)

McFarland discusses Kant's concept of teleology only insofar as it pertains to natural science, although the concept also has importance for Kant's aesthetics, ethics, and philosophies of history and religion. The study is devoted to an explication of the concept--rather than a developed interpretation-written from the belief that there is "no similar attempt to deal strictly with Kant's treatment of teleology." McFarland is apparently unaware of Klaus Düsing's more comprehensive treatment of the concept in Die Teleologie in Kants Weltbegriff which (...) includes a bibliography of the literature on the subject. Nevertheless, McFarland does draw attention to several crucial aspects of Kant's view and places it in historical perspective, showing its similarity to Hume's argument in the Dialogues. The author points out that teleology functions as a regulative concept for Kant; although we cannot attribute design to the composition of the world, we can use it heuristically to lead us to new mechanical explanations and toward a systematization of knowledge. Moreover, as a subjective principle it enables us to make sense out of organic beings which are unintelligible to us on mechanical models. McFarland argues that since organic purposiveness is a subjective principle of organization it cannot be used to solve the problem of induction and that Kant has not explained why empirical laws are objectively necessary. Although this book omits much, it will be useful to the reader desiring a brief explanation of how Kant uses the concept in parts of the first Critique and in the Critique of Teleological Judgement.--T. P. A. (shrink)